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Commentary on Dysentery amoebiasis’s Symptoms, Causes, and Treatment
Dysentery amoebiasis or amoebic dysentery or amebiasis is described as a gastrointestinal infection caused by a parasite called Entamoeba histolytica, with or without clinical signs. Although 90% of E. histolytica infections are asymptomatic, amoebiasis might present symptoms such as diarrhea that contains blood or mucus. This disease is commonly caused by consuming food or water contaminated by feces containing E. histolytica cyst, the infectious form of the parasite, but it can also be spread sexually by oral-anal contact. Infection occurs worldwide but it is more common in low-income countries with inadequate public health. Developing countries of Central and South America, Africa, and Asia have high rates of infection. Amebiasis generally affects individuals of all ages and there is no gender difference in amebiasis in children. However, invasive disease is more common in males than females in the adult population.
Amebiasis symptoms vary from asymptomatic to rare severe infection. Amebiasis has two main clinical forms: intestinal and extraintestinal. E. histolytica primarily causes intestinal amebiasis and symptoms typically appear gradually over one to three weeks. Common symptoms include diarrhea, bloody stools, nausea and vomiting, stomach pain, weight loss, and high fever.
Extraintestinal amebiasis happens when the parasite enters the bloodstream, it can spread through the body and reach organs like liver, lungs, and brain. Extraintestinal amebiasis is characterized by a variety of illnesses depending on the affected organ. The two most common types of extraintestinal amebiasis are hepatic and pulmonary amebiasis. Amoebic liver abscess (collection of pus in the liver) can develop months or years after an individual has been exposed. Symptoms include fever, soreness in the right upper quadrant, and less than 10% of patients experience jaundice. Pulmonary involvement of the disease can result in symptoms including fever, coughing, and respiratory discomfort.
Diarrhea is defined as increase in water content in stools caused by an imbalance in the normal functioning of intestines that are responsible for the absorption of different ions, other substrates, and ultimately water. Diarrhea is categorized into acute or chronic and infectious or non-infectious. Infection is the common cause of diarrhea and most cases are caused by viral infection so typically characterized by non-bloody watery stools. On the other hand, dysentery is an intestinal infection that causes bloody or mucus-filled diarrhea. There are two main types of dysentery, amoebic and bacillary dysentery.
Amebiasis can be diagnosed by observing the organism using direct microscopy of stools or rectal swabs. If your doctor suspects you have dysentery, they will request a stool culture and send your sample to a laboratorium. However cultures are not always positive with a success rate of roughly 60% and present in only 30% of cases. The severity of your diarrhea can be determined by a complete blood count, electrolyte measurements, and kidney function test. A colonoscopy can also be considered suitable when the stool tests are negative for amebiasis. Your physician may order additional testing like CT scan particularly in extraintestinal amebiasis cases.
Dysentery is potentially fatal and extremely dangerous if not treated properly especially to young children, people over the age of 50, pregnant women, and those who have dehydration or malnutrition. The mortality rate is less than 1% for patients who have uncomplicated infections and receive early treatment. Thus, all E. histolytica infection must be treated to eliminate the possibility of spreading and developing extraintestinal symptoms. Patients should contact their healthcare provider if they have symptoms of diarrhea and bloody stools to receive further examination and proper treatment. Treatment of this disease includes antibiotics that must be prescribed by a physician and symptomatic medication such as antiemetic. Patients are also advised to drink plenty of fluid to prevent dehydration.
Good hand hygiene: wash your hands with soap and running water after going to the bathroom, handling trash, and touching animals, also before handling or eating food
Wash all fruit and vegetables with clean running water and peel them before eating them
Avoid undercooked fish or meats and thoroughly cook all food
Don’t use water for consumption like drinking, brushing your teeth, or cooking if you’re not sure whether it’s sanitized or sterile
Stay away from people who have dysentery for the risk of transmission
Do not share towels, toothbrush, cups, or other personal items especially with those who has dysentery
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References:
Nasrallah J, Akhoundi M, Haouchine D, Marteau A, Mantelet S, Wind P, et al. Updates on the worldwide burden of amoebiasis: A case series and literature review. J Infect Public Health [Internet]. 2022;15(10):1134–41. Available from: http://dx.doi.org/10.1016/j.jiph.2022.08.013
Zulfiqar H, Mathew G, Horrall S. Amebiasis. StatPearls Publishing; 2023.
Morán P, Serrano-Vázquez A, Rojas-Velázquez L, González E, Pérez-Juárez H, Hernández EG, et al. Amoebiasis: Advances in diagnosis, treatment, immunology features and the interaction with the intestinal ecosystem. Int J Mol Sci [Internet]. 2023 [cited 2024 Jul 3];24(14):11755. Available from: http://dx.doi.org/10.3390/ijms241411755
Chou A, Austin RL. Entamoeba histolytica Infection. StatPearls Publishing; 2023.
Amebiasis [Internet]. Cdc.gov. 2019 [cited 2024 Jul 3]. Available from: https://www.cdc.gov/dpdx/amebiasis/index.html
Nemeth V, Pfleghaar N. Diarrhea. StatPearls Publishing; 2022.
Barr W, Smith A. Acute diarrhea in adults. afp [Internet].
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from: https://www.aafp.org/pubs/afp/issues/2014/0201/p180.html
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